Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.

Journal article

Tumor necrosis factor (TNF) alpha has been shown to be a major therapeutic target in rheumatoid arthritis with the success of anti-TNFalpha antibody clinical trials. Although signaling pathways leading to TNFalpha expression have been studied in some detail, there is evidence for considerable differences between individual cell types. This prompted us to investigate the intracellular signaling pathways that result in increased TNFalpha synthesis from macrophages in the diseased synovial joint...

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Authors: Foxwell, B; Browne, K; Bondeson, J; Clarke, C; de Martin, R

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 95
• Issue: 14
• Pages: 8211-8215
• Publication date: 1998-07-01
• DOI: 10.1073/pnas.95.14.8211
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Adenoviridae; Signal Transduction; Humans; I-kappa B Proteins; Arthritis, Rheumatoid; Gene Expression Regulation; Genetic Vectors; NF-kappa B; Macrophages; DNA-Binding Proteins; Tumor Necrosis Factor-alpha