Journal article
An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns
- Abstract:
-
Rho GTPase-based signaling networks control cellular dynamics by coordinating protrusions and retractions in space and time. Here, we reveal a signaling network that generates pulses and propagating waves of cell contractions. These dynamic patterns emerge via self organization from an activator-inhibitor network, in which the small GTPase Rho amplifies its activity by recruiting its activator, GEF-H1. Rho also inhibits itself by local recruitment of acto myosin and the associated RhoGAP Myo9...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Marie Skłodowska-Curie Innovative Training Network InCeM
More from this funder
Grant:
642866
H2020-MSCA-ITN-2014
Bibliographic Details
- Publisher:
- Rockefeller university Press Publisher's website
- Journal:
- Journal of Cell Biology Journal website
- Volume:
- 216
- Issue:
- 12
- Pages:
- 4271-4285
- Publication date:
- 2017-10-20
- Acceptance date:
- 2017-09-08
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
Item Description
- Pubs id:
-
pubs:738161
- UUID:
-
uuid:8942abd8-7def-48f9-a20d-adf9c73c5320
- Local pid:
- pubs:738161
- Source identifiers:
-
738161
- Deposit date:
- 2017-10-22
Terms of use
- Copyright holder:
- Graessl et al
- Copyright date:
- 2017
- Notes:
-
This article is distributed under the terms of an Attribution–
Noncommercial–Share Alike–No Mirror Sites license for the first six months after the
publication date (see http://www.rupress.org/terms/). After six months it is available under
a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International
license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record