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An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns

Abstract:

Rho GTPase-based signaling networks control cellular dynamics by coordinating protrusions and retractions in space and time. Here, we reveal a signaling network that generates pulses and propagating waves of cell contractions. These dynamic patterns emerge via self organization from an activator-inhibitor network, in which the small GTPase Rho amplifies its activity by recruiting its activator, GEF-H1. Rho also inhibits itself by local recruitment of acto myosin and the associated RhoGAP Myo9...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.201706052

Authors


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Institution:
University of Oxford
Division:
MPLS
Role:
Author
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Name:
MERCUR
Grant:
Pr-2012-0022
More from this funder
Name:
Marie Skłodowska-Curie Innovative Training Network InCeM
Grant:
642866
H2020-MSCA-ITN-2014
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Name:
Deutsche Forschungsgemeinschaft
Grant:
SPP 1462/2
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Name:
Bundesministerium für Bildung und Forschung
Grant:
0315258
Publisher:
Rockefeller university Press
Journal:
Journal of Cell Biology More from this journal
Volume:
216
Issue:
12
Pages:
4271-4285
Publication date:
2017-10-20
Acceptance date:
2017-09-08
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pubs id:
pubs:738161
UUID:
uuid:8942abd8-7def-48f9-a20d-adf9c73c5320
Local pid:
pubs:738161
Source identifiers:
738161
Deposit date:
2017-10-22

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