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Thesis

The identification and characterisation of germline genetic variants that affect human cancer

Abstract:

Single nucleotide polymorphisms (SNPs) have great potential to serve as important biomarkers in the clinic to identify those at increased risk for developing cancer, progressing more rapidly, and not responding to therapies. However, the clinical application of cancer-associated SNPs has proven to be more complicated than expected. One of the necessary steps will certainly be the description of the molecular and cellular mechanisms behind the observed associations. The p53 tumour suppresso...

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Institution:
University of Oxford
Research group:
Ludwig Institute for Cancer Research
Oxford college:
St Catherine's College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author

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Role:
Supervisor
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Funding agency for:
Jorge Zeron-Medina Cuairan
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:8942602e-c0f8-4793-8020-d2eadd41b252
Local pid:
ora:8848
Language:
English
Keywords:
Subjects:

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