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Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay.

Abstract:

1. The pharmacokinetic and effect kinetic properties of oral (p.o.), intramuscular (i.m.), and intrarectal (i.r.) artemether (5 mg kg-1) were compared in a crossover study in eight healthy adult volunteers. Plasma concentrations of artemether (AM) and its active metabolite dihydroartemisinin (DHA) were measured by high performance liquid chromatography with reductive mode electrochemical detection (h.p.l.c.-ECD), and plasma antimalarial activity in vitro (effect) was assessed on the same samp...

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Publication status:
Published

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Journal:
British journal of clinical pharmacology
Volume:
42
Issue:
5
Pages:
599-604
Publication date:
1996-11-01
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
Source identifiers:
13788
Language:
English
Keywords:
Pubs id:
pubs:13788
UUID:
uuid:8937fa2f-20c9-4f98-bca2-9be5ec6c2146
Local pid:
pubs:13788
Deposit date:
2012-12-19

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