Journal article
Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay.
- Abstract:
-
1. The pharmacokinetic and effect kinetic properties of oral (p.o.), intramuscular (i.m.), and intrarectal (i.r.) artemether (5 mg kg-1) were compared in a crossover study in eight healthy adult volunteers. Plasma concentrations of artemether (AM) and its active metabolite dihydroartemisinin (DHA) were measured by high performance liquid chromatography with reductive mode electrochemical detection (h.p.l.c.-ECD), and plasma antimalarial activity in vitro (effect) was assessed on the same samp...
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- Publication status:
- Published
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- Publisher copy:
- 10.1111/j.1365-2125.1996.tb00115.x
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Bibliographic Details
- Journal:
- British journal of clinical pharmacology
- Volume:
- 42
- Issue:
- 5
- Pages:
- 599-604
- Publication date:
- 1996-11-01
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- Source identifiers:
-
13788
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:13788
- UUID:
-
uuid:8937fa2f-20c9-4f98-bca2-9be5ec6c2146
- Local pid:
- pubs:13788
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1996
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