Journal article icon

Journal article

Interaction of reducible polypeptide gene delivery vectors with supported lipid bilayers: pore formation and structure-function relationships

Abstract:

Real-time atomic force microscopy (AFM) in aqueous buffer has been used to probe interactions of synthetic disulfide-linked polypeptide gene delivery vectors with supported phospholipid bilayers. Disruption of the membranes was apparent in AFM, and the extent of surface heterogeneity and hole (pore) formation was evaluated by depth and area-profiling image analysis. The overall extent of membrane disruption varied with the reducible polycation peptide sequence and block structure and was foun...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1039/b927204f

Authors


Expand authors...
Journal:
SOFT MATTER
Volume:
6
Issue:
11
Pages:
2517-2524
Publication date:
2010-01-01
DOI:
EISSN:
1744-6848
ISSN:
1744-683X
Source identifiers:
178975
Language:
English
Pubs id:
pubs:178975
UUID:
uuid:892f4bac-7865-4441-9795-349d8e58076c
Local pid:
pubs:178975
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP