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Dengue and Zika virus cross-reactive human monoclonal antibodies protect against Spondweni virus infection and pathogenesis in mice

Abstract:

Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains failed to cause disease in immunocompetent mice, each accumulated in the brain, spleen, eye, testis, and kidney when type I interferon signaling was blocked and unexpectedly caused i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.celrep.2019.01.052

Authors


Salazar, V More by this author
Jagger, BW More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Burgomaster, KE More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
26
Issue:
6
Pages:
1585-1597
Publication date:
2019-02-05
Acceptance date:
2019-01-15
DOI:
ISSN:
2211-1247
Pubs id:
pubs:969980
URN:
uri:892879c9-caa7-4f75-b1f9-1f22c5203fc5
UUID:
uuid:892879c9-caa7-4f75-b1f9-1f22c5203fc5
Local pid:
pubs:969980

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