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Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1.

Abstract:

Superantigens stimulate T cells bearing particular T-cell receptor V beta sequences, so they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding of superantigens to class II major histocompatibility complex (MHC) molecules. To further the structural characterization of these interactions, the crystal structure of a toxin associated with toxic-shock syndrome, TSST-1, which is a microbial superantigen, has been determined at 2.5 A resolution. The N- and C-t...

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Publication status:
Published

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Publisher copy:
10.1038/367094a0

Authors


Acharya, KR More by this author
Passalacqua, EF More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
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Journal:
Nature
Volume:
367
Issue:
6458
Pages:
94-97
Publication date:
1994-01-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:8922e1e6-1918-49b7-b0bc-14dfb3f552ee
Source identifiers:
26961
Local pid:
pubs:26961

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