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Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'.

Abstract:

BACKGROUND: Blood concentrations of fibrinogen have been associated with coronary heart disease risk in epidemiological studies, but it is uncertain whether this association is causal or reflects residual confounding by other risk factors. We investigated the relationship between the single nucleotide polymorphism at position -148 in the beta-fibrinogen gene promoter (beta - 148C/T), blood fibrinogen levels, and risk of myocardial infarction (MI) in sufficiently large numbers of coronary dis...

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Publication status:
Published

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Publisher copy:
10.1093/ije/dyl114

Authors


Keavney, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
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Journal:
International journal of epidemiology
Volume:
35
Issue:
4
Pages:
935-943
Publication date:
2006-08-05
DOI:
EISSN:
1464-3685
ISSN:
0300-5771
URN:
uuid:891dc44b-23d9-4a45-b41c-705d5009ec97
Source identifiers:
40058
Local pid:
pubs:40058

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