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Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation.

Abstract:

Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was assoc...

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Publication status:
Published

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Journal:
Blood
Volume:
113
Issue:
10
Pages:
2298-2301
Publication date:
2009-03-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
161159

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