Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.

Journal article

BACKGROUND: Despite strong evidence implicating immune dysfunction and genetic predisposition in the pathogenesis of the chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis, the importance of the genes of the major histocompatibility complex remains uncertain. We have investigated the contribution of HLA DRB1 and DQB genes by the strategies of non-parametric linkage analysis (affected sibling pair method) as well as association study. The relation between genotype and ...

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Authors: Satsangi, J; Welsh, K; Bunce, M; Julier, C; Farrant, J

• Publication status: Published
• Journal: Lancet
• Volume: 347
• Issue: 9010
• Pages: 1212-1217
• Publication date: 1996-05-01
• DOI: 10.1016/s0140-6736(96)90734-5
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Female; Inflammatory Bowel Diseases; Genes, MHC Class II; Genetic Predisposition to Disease; Genetic Linkage; Alleles; Colitis, Ulcerative; HLA-DQ Antigens; Phenotype; HLA-DR Antigens; Crohn Disease; Haplotypes; Middle Aged; Adult; Male; Humans