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Reflections on meta-analyses involving trials stopped early for benefit: is there a problem and if so, what is it?

Abstract:

We review controversies associated with randomized controlled trials (RCTs) stopped early for apparent benefit (truncated RCTs or tRCTs) and present our groups' perspective. Long-established theory, simulations and recent empirical evidence demonstrate that tRCTs will on average overestimate treatment effects, and this overestimation may be large, particularly when tRCTs have small number of events. Theoretical considerations and simulations demonstrate that on average, meta-analyses of RCTs ...

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Publication status:
Published

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Publisher copy:
10.1177/0962280211432211

Authors


Bassler, D More by this author
Montori, VM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Walter, SD More by this author
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Journal:
Statistical methods in medical research
Volume:
22
Issue:
2
Pages:
159-168
Publication date:
2013-04-05
DOI:
EISSN:
1477-0334
ISSN:
0962-2802
URN:
uuid:8913c941-4d1e-4560-bd19-f925cde9c613
Source identifiers:
221741
Local pid:
pubs:221741

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