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Reflections on meta-analyses involving trials stopped early for benefit: is there a problem and if so, what is it?

Abstract:

We review controversies associated with randomized controlled trials (RCTs) stopped early for apparent benefit (truncated RCTs or tRCTs) and present our groups' perspective. Long-established theory, simulations and recent empirical evidence demonstrate that tRCTs will on average overestimate treatment effects, and this overestimation may be large, particularly when tRCTs have small number of events. Theoretical considerations and simulations demonstrate that on average, meta-analyses of RCTs ...

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Publication status:
Published

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Publisher copy:
10.1177/0962280211432211

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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
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Journal:
Statistical methods in medical research
Volume:
22
Issue:
2
Pages:
159-168
Publication date:
2013-04-01
DOI:
EISSN:
1477-0334
ISSN:
0962-2802
Source identifiers:
221741
Language:
English
Keywords:
Pubs id:
pubs:221741
UUID:
uuid:8913c941-4d1e-4560-bd19-f925cde9c613
Local pid:
pubs:221741
Deposit date:
2012-12-19

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