Localization of Nogo and its receptor in the optic pathway of mouse embryos.
We have investigated the localization of Nogo, an inhibitory protein acting on regenerating axons in the adult central nervous system, in the embryonic mouse retinofugal pathway during the major period of axon growth into the optic chiasm. In the retina, Nogo protein was localized on the neuroepithelial cells at E12 and at later stages (E13-E17) on radial glial cells. Colocalization studies showed expression of Nogo on vimentin-positive glia in the retina and at the optic nerve head but not o...Expand abstract
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