- Abstract:
-
Inhibitory receptors are required for the control of cellular activation and they play essential roles in regulating homeostasis and immunity. We previously identified a human inhibitory C-type lectin-like receptor, MICL (CLEC12A), a heavily glycosylated monomer predominantly expressed on myeloid cells. Here we characterise the murine homolog of MICL (mMICL), and demonstrate that the receptor is structurally and functionally similar to the human orthologue (hMICL), although there are some not...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/eji.200738057
-
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- Journal:
- European journal of immunology
- Volume:
- 38
- Issue:
- 4
- Pages:
- 1157-1163
- Publication date:
- 2008-04-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:891044f3-3ec9-4e21-917f-32bed2e41da1
- Source identifiers:
-
15568
- Local pid:
- pubs:15568
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand.
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