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Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand.

Abstract:

Inhibitory receptors are required for the control of cellular activation and they play essential roles in regulating homeostasis and immunity. We previously identified a human inhibitory C-type lectin-like receptor, MICL (CLEC12A), a heavily glycosylated monomer predominantly expressed on myeloid cells. Here we characterise the murine homolog of MICL (mMICL), and demonstrate that the receptor is structurally and functionally similar to the human orthologue (hMICL), although there are some not...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200738057

Authors


Huysamen, C More by this author
Marshall, AS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Taylor, PR More by this author
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Journal:
European journal of immunology
Volume:
38
Issue:
4
Pages:
1157-1163
Publication date:
2008-04-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:891044f3-3ec9-4e21-917f-32bed2e41da1
Source identifiers:
15568
Local pid:
pubs:15568

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