Endothelial and platelet microparticles in vasculitis of the young.

Journal article

OBJECTIVE: Microparticles are released from endothelial cells in response to a variety of injurious stimuli and recently have been shown to be increased in a number of diseases associated with endothelial dysfunction. This study examined endothelial microparticle (EMP) and platelet microparticle (PMP) profiles in children with systemic vasculitis to test the hypothesis that EMPs may provide a noninvasive means of examining endothelial activation or injury. METHODS: The study cohort comprised ...

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Authors: Brogan, P; Shah, V; Brachet, C; Harnden, A; Mant, D

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 50
• Issue: 3
• Pages: 927-936
• Publication date: 2004-03-01
• DOI: 10.1002/art.20199
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Cohort Studies; Particle Size; Endothelium, Vascular; Acute-Phase Proteins; Remission Induction; Antigens, CD; Infant; Platelet Glycoprotein GPIb-IX Complex; Receptors, Cell Surface; Vascular Cell Adhesion Molecule-1; Female; Male; Humans; Vasculitis; Blood Platelets; Fever; Child; Longitudinal Studies; Adolescent; Child, Preschool; Case-Control Studies