Differentiated baroreflex modulation of sympathetic nerve activity during deep brain stimulation in humans.

Journal article

Targeted electric deep brain stimulation in midbrain nuclei in humans alters cardiovascular parameters, presumably by modulating autonomic and baroreflex function. Baroreflex modulation of sympathetic outflow is crucial for cardiovascular regulation and is hypothesized to occur at 2 distinct brain locations. The aim of this study was to evaluate sympathetic outflow in humans with deep brain stimulating electrodes during ON and OFF stimulation of specific midbrain nuclei known to regulate card...

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Authors: Sverrisdóttir, Y; Green, A; Aziz, T; Bahuri, N; Hyam, J

• Publication status: Published
• Journal: Hypertension
• Volume: 63
• Issue: 5
• Pages: 1000-1010
• Publication date: 2014-05-01
• DOI: 10.1161/hypertensionaha.113.02970
• EISSN: 1524-4563
• ISSN: 0194-911X
• Language: English
• Keywords: Blood Pressure; Sympathetic Nervous System; Chronic Disease; Random Allocation; Cardiovascular Physiological Processes; Treatment Outcome; Humans; Neuralgia; Heart Rate; Periaqueductal Gray; Baroreflex; Subthalamic Nucleus; Deep Brain Stimulation; Parkinson Disease