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Pancreatic beta cells express the fetal islet hormone gastrin in rodent and human diabetes

Abstract:

Beta-cell failure in type 2 diabetes (T2D) was recently proposed to involve dedifferentiation of beta-cells and ectopic expression of other islet hormones, including somatostatin and glucagon. Here we show that gastrin, a stomach hormone typically expressed in the pancreas only during embryogenesis, is expressed in islets of diabetic rodents and humans with T2D. While in mice gastrin is expressed insulin+ cells, in humans with T2D gastrin expression occurs in both insulin+ and somatostatin+ c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.2337/db16-0641

Authors


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Soyka Pancreatic Cancer Fund More from this funder
Juvenile Diabetes Research Foundation More from this funder
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Grant:
BetaCellBiologyConsortium
theHumanIsletResearchNetworkofthe NIH(DK104216,DK104119
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
66
Issue:
2
Pages:
426-436
Publication date:
2016-11-18
Acceptance date:
2016-11-10
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
663850
Language:
English
Keywords:
Pubs id:
pubs:663850
UUID:
uuid:88f68694-d53c-4115-906a-f788fc441c6d
Local pid:
pubs:663850
Deposit date:
2017-01-13

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