Journal article icon

Journal article

Pancreatic beta cells express the fetal islet hormone gastrin in rodent and human diabetes

Abstract:

Beta-cell failure in type 2 diabetes (T2D) was recently proposed to involve dedifferentiation of beta-cells and ectopic expression of other islet hormones, including somatostatin and glucagon. Here we show that gastrin, a stomach hormone typically expressed in the pancreas only during embryogenesis, is expressed in islets of diabetic rodents and humans with T2D. While in mice gastrin is expressed insulin+ cells, in humans with T2D gastrin expression occurs in both insulin+ and somatostatin+ c...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.2337/db16-0641

Authors


Expand authors...
Juvenile Diabetes Research Foundation More from this funder
More from this funder
Grant:
Beta Cell Biology Consortium and the Human Islet Research Network of the NIH (DK104216, DK104119)
Helmsley Charitable Trust More from this funder
Expand funders...
Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
66
Issue:
2
Pages:
426-436
Publication date:
2016-11-18
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pubs id:
pubs:663850
URN:
uri:88f68694-d53c-4115-906a-f788fc441c6d
UUID:
uuid:88f68694-d53c-4115-906a-f788fc441c6d
Local pid:
pubs:663850
Paper number:
2
Language:
English
Keywords:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP