Cardiac nitric oxide: emerging role for nNOS in regulating physiological function.

Journal article

Emerging evidence shows that neuronal nitric oxide synthase (nNOS) plays several diverging roles in modulating cardiac function. This review examines the nitric oxide (NO) pathway and the regulatory mechanisms to which nNOS signalling is sensitive. These mechanisms are diverse and include regulation of gene expression, posttranscriptional regulation, protein trafficking, allosteric modulation of nNOS and redox modification to alter NO bioavailability once synthesised. Functionally, alteration...

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Authors: Danson, E; Choate, J; Paterson, D

• Publication status: Published
• Journal: Pharmacology and therapeutics
• Volume: 106
• Issue: 1
• Pages: 57-74
• Publication date: 2005-04-01
• DOI: 10.1016/j.pharmthera.2004.11.003
• EISSN: 1879-016X
• ISSN: 0163-7258
• Language: English
• Keywords: Heart; Signal Transduction; Nerve Tissue Proteins; Myocardium; Nitric Oxide Synthase; Animals; Oxidation-Reduction; Protein Transport; Nitric Oxide; Allosteric Regulation; Nitric Oxide Synthase Type I; Humans; Gene Expression Regulation, Enzymologic