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In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen.

Abstract:

T cells recognizing poorly displayed self determinants escape tolerance mechanisms and persist in the adult repertoire. The process by which these T cells are primed is not clear, but once activated, they can cause autoimmunity. Here, we show that dendritic cells treated with interleukin 6 (IL-6) process and present determinants from a model native antigen in a qualitatively altered hierarchy, activating T cells in vitro and in vivo against determinants that were previously cryptic because of...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.95.25.14903

Authors


Drakesmith, H More by this author
Schneider, SC More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
95
Issue:
25
Pages:
14903-14908
Publication date:
1998-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:88f0eeb9-7d9e-499d-9f23-db895df77ce3
Source identifiers:
49999
Local pid:
pubs:49999

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