- Abstract:
-
T cells recognizing poorly displayed self determinants escape tolerance mechanisms and persist in the adult repertoire. The process by which these T cells are primed is not clear, but once activated, they can cause autoimmunity. Here, we show that dendritic cells treated with interleukin 6 (IL-6) process and present determinants from a model native antigen in a qualitatively altered hierarchy, activating T cells in vitro and in vivo against determinants that were previously cryptic because of...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.95.25.14903
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 95
- Issue:
- 25
- Pages:
- 14903-14908
- Publication date:
- 1998-12-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:88f0eeb9-7d9e-499d-9f23-db895df77ce3
- Source identifiers:
-
49999
- Local pid:
- pubs:49999
- Copyright date:
- 1998
Journal article
In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen.
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