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The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55).

Abstract:

Echovirus type 12 (EV12), an Enterovirus of the Picornaviridae family, uses the complement regulator decay-accelerating factor (DAF, CD55) as a cellular receptor. We have calculated a three-dimensional reconstruction of EV12 bound to a fragment of DAF consisting of short consensus repeat domains 3 and 4 from cryo-negative stain electron microscopy data (EMD code 1057). This shows that, as for an earlier reconstruction of the related echovirus type 7 bound to DAF, attachment is not within the ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m311334200

Authors


Goodfellow, IG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Pettigrew, D More by this author
Chaudhry, Y More by this author
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Journal:
The Journal of biological chemistry
Volume:
279
Issue:
9
Pages:
8325-8332
Publication date:
2004-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:88f08af5-29bc-41c1-917a-bb33c0dd4dae
Source identifiers:
14396
Local pid:
pubs:14396

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