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Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles

Abstract:

The ATP-sensitive potassium (KATP) channel is a hetero-octameric complex that links cell metabolism to membrane electrical activity in many cells, thereby controlling physiological functions such as insulin release, muscle contraction and neuronal activity. It consists of four pore-forming Kir6.2 and four regulatory sulfonylurea receptor (SUR) subunits. SUR2B serves as the regulatory subunit in smooth muscle and some neurones. An integrative approach, combining electron microscopy and homolog...

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Publisher copy:
10.1111/febs.12097

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
FEBS Journal
Volume:
280
Issue:
4
Pages:
1051-1063
Publication date:
2013-02-05
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:88ef9602-1e1b-4ce2-a940-6836ac0334f4
Source identifiers:
388210
Local pid:
pubs:388210

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