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Journal article

Uncertainty in homology inferences: assessing and improving genomic sequence alignment.

Abstract:

Sequence alignment underpins all of comparative genomics, yet it remains an incompletely solved problem. In particular, the statistical uncertainty within inferred alignments is often disregarded, while parametric or phylogenetic inferences are considered meaningless without confidence estimates. Here, we report on a theoretical and simulation study of pairwise alignments of genomic DNA at human-mouse divergence. We find that >15% of aligned bases are incorrect in existing whole-genome ali...

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Publication status:
Published

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Publisher copy:
10.1101/gr.6725608

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Genome research
Volume:
18
Issue:
2
Pages:
298-309
Publication date:
2008-02-01
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Source identifiers:
67928
Language:
English
Keywords:
Pubs id:
pubs:67928
UUID:
uuid:88eca68d-82c1-4b84-ac3a-e48f3f71a7bc
Local pid:
pubs:67928
Deposit date:
2012-12-19

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