T cell receptor alpha chain polymorphisms in multiple sclerosis.

Journal article

Numerous studies have implicated the major histocompatibility complex (MHC) class II alleles, DR2 and DQw1, as multiple sclerosis (MS) susceptibility loci, however, the involvement of other loci is implied by twin studies and the relative lack of haplotype sharing for MHC. To evaluate the role that the TCR alpha chain genes may have in MS susceptibility, three variable (V) alpha polymorphisms were examined for associations in MS patients. Genotype and allele frequencies were compared to four ...

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Authors: Hashimoto, L; Mak, T; Ebers, G

• Publication status: Published
• Journal: Journal of neuroimmunology
• Volume: 40
• Issue: 1
• Pages: 41-48
• Publication date: 1992-09-01
• DOI: 10.1016/0165-5728(92)90211-3
• EISSN: 1872-8421
• ISSN: 0165-5728
• Language: English
• Keywords: Gene Frequency; Polymorphism, Genetic; Multiple Sclerosis; Genotype; Alleles; Receptors, Antigen, T-Cell, alpha-beta; Humans; Haplotypes