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A randomised trial evaluating the safety and immunogenicity of the novel single oral dose typhoid vaccine M01ZH09 in healthy Vietnamese children.

Abstract:

BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages. M01ZH09 is a live oral single dose candidate typhoid vaccine containing Salmonella enterica serovar Typhi (Ty2 aroC(-)ssaV(-)) ZH9 with two independently attenuating deletions. Studies in healthy adults demonstrated immunogenicity and an acceptable safety profile. OBJECTIVES: We conducted a randomised placebo controlle...

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Journal:
PloS one
Volume:
5
Issue:
7
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
Pubs id:
pubs:94834
UUID:
uuid:88e66efa-760c-4284-a514-5d7a7a68f876
Local pid:
pubs:94834
Source identifiers:
94834
Deposit date:
2013-09-17

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