Do height-related variations in insulin-like growth factors underlie the associations of stature with adult chronic disease?

Journal article

Tall people, particularly those with long legs, have an increased risk of developing cancer but a reduced risk of cardiovascular disease and type II diabetes. We examined associations of stature and body mass index with IGF-I, IGF-II, and IGF binding protein (IGFBP)-2 and IGFBP-3 in 274 men aged 50-70 yr to investigate whether variations in growth factor levels underlie associations of anthropometry with a number of adult diseases. Height and leg and trunk length were not strongly associated ...

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Authors: Gunnell, D; Oliver, SE; Donovan, J; Peters, T; Gillatt, D

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 89
• Issue: 1
• Pages: 213-218
• Publication date: 2004-01-01
• DOI: 10.1210/jc.2003-030507
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Body Mass Index; Anthropometry; Insulin-Like Growth Factor II; Body Constitution; Humans; Insulin-Like Growth Factor I; Leg; Insulin-Like Growth Factor Binding Protein 2; Body Height; Middle Aged; Somatomedins; Chronic Disease; Insulin-Like Growth Factor Binding Protein 3; Male; Aged