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Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Abstract:

Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We ...

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Publisher copy:
10.1038/ng.1081

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
Nature Genetics
Volume:
44
Issue:
3
Pages:
328-333
Publication date:
2012-03-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:88de33af-1658-47de-9a86-eb279f0e9e22
Source identifiers:
342921
Local pid:
pubs:342921

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