Journal article
PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
- Abstract:
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Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall activity and the phosphatases that control Greatwall kinase and its substrates are poorly understood. To address these questions we applied a combination of mathematical modelling and experiments using ph...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 7.9MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pgen.1004004
Authors
Funding
+ European Commission
More from this funder
Funding agency for:
Vinod, P
Novák, B
Grant:
FP7 grant EC FP7 MitoSys (241548
FP7 grant EC FP7 MitoSys (241548
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS Genetics More from this journal
- Volume:
- 10
- Issue:
- 1
- Pages:
- e1004004
- Publication date:
- 2014-01-02
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:445855
- UUID:
-
uuid:88de1395-c95c-4459-94d7-69a24cc03213
- Local pid:
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pubs:445855
- Source identifiers:
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445855
- Deposit date:
-
2016-02-15
Terms of use
- Copyright holder:
- Hégarat et al
- Copyright date:
- 2014
- Notes:
- © 2014 Hégarat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License. This is the publisher's version of the article. The final version is available online from the Public Library of Science at: [10.1371/journal.pgen.1004004]
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