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Rapid diagnostic tests as a source of dengue virus RNA for envelope gene amplification: a proof of concept

Abstract:

Molecular epidemiological data are key for dengue outbreak characterization and preparedness. However, sparse Dengue virus (DENV) molecular information is available in Laos because of limited resources. In this proof-of-concept study, we evaluated whether DENV1 RNA extracted from rapid diagnostic tests (RDTs) could be amplified and sequenced. The protocol for envelope gene amplification from RNA purified from RDTs was first assessed using viral isolate dilutions then conducted using 14 dengue...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4269/ajtmh.18-0831

Authors


Publisher:
American Society of Tropical Medicine and Hygiene
Journal:
American Journal of Tropical Medicine and Hygiene More from this journal
Volume:
101
Issue:
2
Pages:
451-455
Publication date:
2019-06-24
Acceptance date:
2019-05-06
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
Pmid:
31237231
Language:
English
Keywords:
Pubs id:
pubs:1024957
UUID:
uuid:88d70a17-0383-47b9-93a3-3fe37bf6a431
Local pid:
pubs:1024957
Source identifiers:
1024957
Deposit date:
2019-11-06

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