An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current I(CRAC) in RBL-1 cells.

Journal article

One popular model for the activation of store-operated Ca2+ influx is the secretion-like coupling mechanism, in which peripheral endoplasmic reticulum moves to the plasma membrane upon store depletion thereby enabling inositol 1,4,5-trisphosphate (InsP3) receptors on the stores to bind to, and thus activate, store-operated Ca2+ channels. This movement is regulated by the underlying cytoskeleton. We have examined the validity of this mechanism for the activation of I(CRAC), the most widely dis...

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Authors: Bakowski, D; Glitsch, M; Parekh, AB

• Publication status: Published
• Journal: Journal of physiology
• Volume: 532
• Issue: Pt 1
• Pages: 55-71
• Publication date: 2001-04-01
• DOI: 10.1111/j.1469-7793.2001.0055g.x
• EISSN: 1469-7793
• ISSN: 0022-3751
• Language: English
• Keywords: Time Factors; Receptors, Cytoplasmic and Nuclear; Depsipeptides; Boron Compounds; Caffeine; Peptides, Cyclic; Rats; Enzyme Inhibitors; Cytochalasin D; Inositol 1,4,5-Trisphosphate Receptors; Nocodazole; Thapsigargin; Inositol 1,4,5-Trisphosphate; Oxazoles; Patch-Clamp Techniques; Animals; Cytoskeleton; Calcium Signaling; Calcium Channels; Cell Size; Microscopy, Fluorescence; Calcium; Lithium; Cell Line; Heparin; Basophils