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Fasting plasma insulin concentrations are associated with changes in hepatic fatty acid synthesis and partitioning prior to changes in liver fat content in healthy adults

Abstract:

Resistance to the action of insulin impacts on fatty acid delivery to the liver, fatty acid synthesis and oxidation within the liver and triglyceride export from the liver. To understand the metabolic consequences of hepatic fatty acid synthesis, partitioning, oxidation and net liver fat content in the fasted and postprandial states we studied healthy men and women with varying degrees of insulin resistance before and after consumption of a mixed meal using stable-isotope tracer methodologies...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.2337/db16-0236

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Henning and Johan Throne-Holst Foundation More from this funder
NIHR Oxford Biomedical Research Centre More from this funder
Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Publication date:
2016-04-19
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pubs id:
pubs:616163
Local pid:
pubs:616163

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