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Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers.

Abstract:

BACKGROUND: Loss of E-cadherin expression has been implicated in the development of invasive characteristics in colorectal carcinomas. Failure to express E-cadherin may result from mutations of the E-cadherin gene (HSECAD). AIMS: To examine the correlation between E-cadherin expression and genetic changes at HSECAD; and to examine differences in E-cadherin expression and genetic changes at HSECAD between three different groups of colorectal cancer--replication error positive (RER+) sporadic c...

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Publication status:
Published

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Publisher copy:
10.1136/gut.40.5.654

Authors


Tomlinson, IP More by this author
Talbot, IC More by this author
Bodmer, WF More by this author
Journal:
Gut
Volume:
40
Issue:
5
Pages:
654-659
Publication date:
1997-05-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:88c32e95-c058-4fd9-956a-0ad0eddc9ee0
Source identifiers:
72323
Local pid:
pubs:72323

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