- Abstract:
-
UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. Recognition of ULBP1 by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells promotes lysis of cells expressing ULBP1 and is an important mechanism of immune surveillance. We report a robust method for the generation of large quantities of crystal-grade recombinant ULBP1 protein. The extracellular portion of human ULBP1 was c...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.pep.2011.04.019
-
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- Journal:
- Protein expression and purification
- Volume:
- 79
- Issue:
- 1
- Pages:
- 44-48
- Publication date:
- 2011-09-05
- DOI:
- EISSN:
-
1096-0279
- ISSN:
-
1046-5928
- URN:
-
uuid:88c2094b-89e8-44ff-a75c-7d755b214c21
- Source identifiers:
-
167671
- Local pid:
- pubs:167671
- Copyright date:
- 2011
Journal article
Expression, purification and crystallization of the human UL16-binding protein ULBP1.
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