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Journal article

Expression, purification and crystallization of the human UL16-binding protein ULBP1.

Abstract:

UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. Recognition of ULBP1 by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells promotes lysis of cells expressing ULBP1 and is an important mechanism of immune surveillance. We report a robust method for the generation of large quantities of crystal-grade recombinant ULBP1 protein. The extracellular portion of human ULBP1 was c...

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Publication status:
Published

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Publisher copy:
10.1016/j.pep.2011.04.019

Authors


Watson, AA More by this author
Christou, CM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Journal:
Protein expression and purification
Volume:
79
Issue:
1
Pages:
44-48
Publication date:
2011-09-05
DOI:
EISSN:
1096-0279
ISSN:
1046-5928
URN:
uuid:88c2094b-89e8-44ff-a75c-7d755b214c21
Source identifiers:
167671
Local pid:
pubs:167671

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