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Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies

Abstract:

Background The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease.

Methods We did a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS). Patients were recruited from hospitals in the UK as part of the UK D...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1474-4422(21)00031-4

Authors


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Role:
Author
ORCID:
0000-0002-9369-5846
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Role:
Author
ORCID:
0000-0001-7689-933X
Publisher:
Elsevier
Journal:
Lancet Neurology More from this journal
Volume:
20
Issue:
5
Pages:
351-361
Publication date:
2021-03-25
Acceptance date:
2021-01-15
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
Pmid:
33773637
Language:
English
Keywords:
Pubs id:
1169788
Local pid:
pubs:1169788
Deposit date:
2021-08-10

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