Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum.

Journal article

1. Depolarization-induced suppression of inhibition (DSI) is a form of synaptic plasticity which involves a retrograde messenger. We have performed experiments in Purkinje cells of rat cerebellar slices to determine the nature of this messenger. 2. DSI is mimicked by 2-(2,3-dicarboxycyclopropyl)-glycine (DCG-IV), a specific agonist of group II metabotropic glutamate receptors (mGluRs). 3. DSI is reduced if transmitter release is inhibited by saturating doses of DCG-IV. 4. Both DSI and DCG-IV-...

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Authors: Glitsch, M; Llano, I; Marty, A

• Publication status: Published
• Journal: Journal of physiology
• Volume: 497 ( Pt 2)
• Issue: 2
• Pages: 531-537
• Publication date: 1996-12-01
• DOI: 10.1113/jphysiol.1996.sp021786
• EISSN: 1469-7793
• ISSN: 0022-3751
• Language: English
• Keywords: Animals; Tetrodotoxin; Forskolin; Rats; Cyclopropanes; Presynaptic Terminals; Electrophysiology; Purkinje Cells; Alanine; 2-Amino-5-phosphonovalerate; Synaptic Transmission; Glutamic Acid; Receptors, Metabotropic Glutamate; Glycine; Benzoates; Kinetics; Excitatory Amino Acid Antagonists; Synapses; Interneurons; Quinoxalines