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Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.

Abstract:

OBJECTIVES: To confirm the association of a functional single-nucleotide polymorphism (SNP), C1858T (rs2476601), in the PTPN22 gene of British Caucasian rheumatoid arthritis (RA) patients and to evaluate its influence on the RA phenotype. METHODS: A total of 686 RA patients and 566 healthy volunteers, all of British Caucasian origin, were genotyped for C1858T polymorphism by PCR-restriction fragment length polymorphism assay. Data were analysed using SPSS software and the chi 2 test as applic...

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Publication status:
Published

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Publisher copy:
10.1093/rheumatology/kei250

Authors


Harrison, P More by this author
Pointon, JJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Rheumatology (Oxford, England)
Volume:
45
Issue:
8
Pages:
1009-1011
Publication date:
2006-08-05
DOI:
EISSN:
1462-0332
ISSN:
1462-0324
URN:
uuid:88b5cea0-1b75-479f-9f40-2e108022ccf7
Source identifiers:
108593
Local pid:
pubs:108593

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