Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.

Journal article

OBJECTIVES: To confirm the association of a functional single-nucleotide polymorphism (SNP), C1858T (rs2476601), in the PTPN22 gene of British Caucasian rheumatoid arthritis (RA) patients and to evaluate its influence on the RA phenotype. METHODS: A total of 686 RA patients and 566 healthy volunteers, all of British Caucasian origin, were genotyped for C1858T polymorphism by PCR-restriction fragment length polymorphism assay. Data were analysed using SPSS software and the chi 2 test as applic...

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Authors: Harrison, P; Pointon, J; Farrar, C; Brown, M; Wordsworth, B

• Publication status: Published
• Journal: Rheumatology (Oxford, England)
• Volume: 45
• Issue: 8
• Pages: 1009-1011
• Publication date: 2006-08-01
• DOI: 10.1093/rheumatology/kei250
• EISSN: 1462-0332
• ISSN: 1462-0324
• Language: English
• Keywords: Female; Humans; Polymerase Chain Reaction; Genetic Predisposition to Disease; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Genotype; Gene Frequency; HLA-DR Antigens; Protein Tyrosine Phosphatases; Polymorphism, Single Nucleotide; Middle Aged; Male; Arthritis, Rheumatoid; Polymorphism, Restriction Fragment Length; Rheumatoid Factor