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Journal article

Contributions of HERG K+ current to repolarization of the human ventricular action potential.

Abstract:

Action potential repolarization in the mammalian heart is governed by interactions of a number of time- and voltage-dependent channel-mediated currents, as well as contributions from the Na+/Ca2+ exchanger and the Na+/K+ pump. Recent work has shown that one of the K+ currents (HERG) which contributes to repolarization in mammalian ventricle is a locus at which a number of point mutations can have significant functional consequences. In addition, the remarkable sensitivity of this K+ channel i...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Progress in biophysics and molecular biology
Volume:
96
Issue:
1-3
Pages:
357-376
Publication date:
2008-01-01
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
Source identifiers:
238896
Language:
English
Keywords:
Pubs id:
pubs:238896
UUID:
uuid:88b05a85-acff-4bc3-9986-3cedf9fe79cd
Local pid:
pubs:238896
Deposit date:
2013-11-16

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