Thesis
The Role of Hypoxia-Regulated MicroRNA in Cancer
- Abstract:
-
MicroRNAs (miRNAs) are short, non-coding RNA sequences which regulate gene expression. Regulation is mediated primarily through binding to complementary sites in their un-translated regions which leads to mRNA degradation or translational repression. Hypoxia is a known feature of many tumours, and increased hypoxia is associated with poor prognosis. Hypoxia leads to the up-regulation of many genes involved in a variety of functions including angiogenesis, a shift to glycolytic metabolism, ...
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Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:88ac4676-c4b2-4c73-a316-4f1ea8abbfe4
- Local pid:
- ora:6727
- Deposit date:
- 2013-02-28
Terms of use
- Copyright holder:
- Robert McCormick
- Copyright date:
- 2011
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