Journal article
R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
- Abstract:
-
The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. Here, we explore the dynamics of Wnt signaling in the colon. We identify two populations of cells with active Wnt signaling: highly proliferative Lgr5+/Axin2+ cells, as well as secretory Lgr5-/Axin2+ cells. Upon Lgr5+ cell depletion, these cells are recruited to contribute to crypt regeneration. Ch...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Issue:
- 1
- Article number:
- 4368
- Publication date:
- 2019-09-25
- Acceptance date:
- 2019-09-04
- DOI:
- ISSN:
-
2041-1723
- Pmid:
-
31554819
Item Description
- Language:
- English
- Pubs id:
-
pubs:1060727
- UUID:
-
uuid:88a8abf8-0af4-4579-8344-6cffb58812f1
- Local pid:
- pubs:1060727
- Source identifiers:
-
1060727
- Deposit date:
- 2019-11-20
Terms of use
- Copyright holder:
- Harnack et al
- Copyright date:
- 2019
- Notes:
-
© The Author(s) 2019. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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