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Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.

Abstract:

The protooncogene c-met codes for the hepatocyte growth factor receptor tyrosine kinase. Binding of its ligand, hepatocyte growth factor/scatter factor, stimulates receptor autophosphorylation, which leads to pleiotropic downstream signaling events in epithelial cells, including cell growth, motility, and invasion. These events are mediated by interaction of cytoplasmic effectors, generally through Src homology 2 (SH2) domains, with two phosphotyrosine-containing sequence motifs in the unique...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1734128100

Authors


Schiering, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Marconi, M More by this author
Flocco, MM More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
100
Issue:
22
Pages:
12654-12659
Publication date:
2003-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:88a417d4-bb21-48d9-b02b-95c8bc44f118
Source identifiers:
375127
Local pid:
pubs:375127

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