Journal article
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.
- Abstract:
-
The protooncogene c-met codes for the hepatocyte growth factor receptor tyrosine kinase. Binding of its ligand, hepatocyte growth factor/scatter factor, stimulates receptor autophosphorylation, which leads to pleiotropic downstream signaling events in epithelial cells, including cell growth, motility, and invasion. These events are mediated by interaction of cytoplasmic effectors, generally through Src homology 2 (SH2) domains, with two phosphotyrosine-containing sequence motifs in the unique...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.1734128100
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 100
- Issue:
- 22
- Pages:
- 12654-12659
- Publication date:
- 2003-10-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:88a417d4-bb21-48d9-b02b-95c8bc44f118
- Source identifiers:
-
375127
- Local pid:
- pubs:375127
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2003
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