- Abstract:
-
The protooncogene c-met codes for the hepatocyte growth factor receptor tyrosine kinase. Binding of its ligand, hepatocyte growth factor/scatter factor, stimulates receptor autophosphorylation, which leads to pleiotropic downstream signaling events in epithelial cells, including cell growth, motility, and invasion. These events are mediated by interaction of cytoplasmic effectors, generally through Src homology 2 (SH2) domains, with two phosphotyrosine-containing sequence motifs in the unique...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1734128100
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 100
- Issue:
- 22
- Pages:
- 12654-12659
- Publication date:
- 2003-10-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:88a417d4-bb21-48d9-b02b-95c8bc44f118
- Source identifiers:
-
375127
- Local pid:
- pubs:375127
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.
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