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Roles of interleaflet coupling and hydrophobic mismatch in lipid membrane phase-separation kinetics

Abstract:

Characterising the nanoscale dynamic organisation of lipids in bilayers is central to our understanding of cell membranes at a molecular level. We investigate phase separation and communication across leaflets in ternary lipid bilayers, including saturated lipids with between 12 and 20 carbons per tail. Coarse-grained molecular dynamics simulations reveal a novel two-step kinetics due to hydrophobic mismatch, in which the initial response of the apposed leaflets upon quenching is to increase...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/jacs.6b04880

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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Fowler, Philip
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
138
Issue:
36
Pages:
11633–11642
Publication date:
2016-01-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:638397
URN:
uri:88a09aba-84cd-4395-b52e-8817264ec237
UUID:
88a09aba-84cd-4395-b52e-8817264ec237
Local pid:
pubs:638397
Paper number:
36
Language:
English

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