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Small molecule antagonists of NAADP-induced Ca2+ release in T-lymphocytes suggest potential therapeutic agents for autoimmune disease

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+-releasing second messenger known to date, but the precise NAADP/Ca2+ signalling mechanisms are still controversial. We report the synthesis of small-molecule inhibitors of NAADP-induced Ca2+ release based upon the nicotinic acid motif. Alkylation of nicotinic acid with a series of bromoacetamides generated a diverse compound library. However, many members were only weakly active or had poor physicochemical propertie...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-018-34917-3

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Cordiglieri, C More by this author
Dammermann, W More by this author
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Funding agency for:
Potter, BVL
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Funding agency for:
Potter, BVL
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Grant:
Biomedical Research Collaboration Grant no. 068065 to BVLP and AHG
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 16775
Publication date:
2018-11-13
Acceptance date:
2018-10-28
DOI:
ISSN:
2045-2322
Pubs id:
pubs:935222
URN:
uri:889cb5cc-33ad-4d93-a928-9e4747045063
UUID:
uuid:889cb5cc-33ad-4d93-a928-9e4747045063
Local pid:
pubs:935222

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