Journal article
Small molecule antagonists of NAADP-induced Ca2+ release in T-lymphocytes suggest potential therapeutic agents for autoimmune disease
- Abstract:
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Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+-releasing second messenger known to date, but the precise NAADP/Ca2+ signalling mechanisms are still controversial. We report the synthesis of small-molecule inhibitors of NAADP-induced Ca2+ release based upon the nicotinic acid motif. Alkylation of nicotinic acid with a series of bromoacetamides generated a diverse compound library. However, many members were only weakly active or had poor physicochemical propertie...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.2MB, Terms of use)
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- Publisher copy:
- 10.1038/s41598-018-34917-3
Authors
Funding
+ University of Bath
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Funding agency for:
Potter, B
Grant:
Enterprise Development Grant
+ Wellcome Trust
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Funding agency for:
Potter, B
Grant:
Enterprise Development Grant
BiomedicalResearchCollaborationGrantno.068065toBVLP
AHG
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Scientific Reports More from this journal
- Volume:
- 8
- Article number:
- 16775
- Publication date:
- 2018-11-13
- Acceptance date:
- 2018-10-28
- DOI:
- ISSN:
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2045-2322
Item Description
- Keywords:
- Pubs id:
-
pubs:935222
- UUID:
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uuid:889cb5cc-33ad-4d93-a928-9e4747045063
- Local pid:
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pubs:935222
- Deposit date:
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2018-10-29
Terms of use
- Copyright holder:
- Zhang et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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