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The G6PD flow-cytometric assay is a reliable tool for diagnosis of G6PD deficiency in women and anaemic subjects

Abstract:

Glucose-6-phosphate dehydrogenase (G6PD) activity is essential for redox equilibrium of red blood cells (RBCs) and, when compromised, the RBCs are more susceptible to haemolysis. 8-aminoquinolines (primaquine and tafenoquine) are used for the radical curative treatment of Plasmodium vivax malaria and can cause haemolysis in G6PD deficient subjects. Haemolytic risk is dependent on treatment dose and patient G6PD status but ultimately it correlates to the number of G6PD deficient red blood cell...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-10045-2

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Funding agency for:
Bancone, G
Grant:
089179
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Funding agency for:
Malleret, B
Grant:
13/1/16/YA/009
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Funding agency for:
Chu, C
Grant:
089179
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
9822
Pages:
1-8
Publication date:
2017-08-29
Acceptance date:
2017-08-02
DOI:
ISSN:
2045-2322
Source identifiers:
724021
Pubs id:
pubs:724021
UUID:
uuid:8884451e-8755-4d39-9555-5b5c9b933c61
Local pid:
pubs:724021
Deposit date:
2017-08-25

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