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Journal article

Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2).

Abstract:

The components of the cellular protein translation machinery, such as ribosomal proteins and translation factors, are subject to numerous post-translational modifications. In particular, this group of proteins is frequently methylated. However, for the majority of these methylations, the responsible methyltransferases (MTases) remain unknown. The human FAM86A (family with sequence similarity 86) protein belongs to a recently identified family of protein MTases, and we here show that FAM86A ca...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m114.601658

Authors


Davydova, E More by this author
Malecki, J More by this author
Enserink, JM More by this author
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Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
The Journal of biological chemistry
Volume:
289
Issue:
44
Pages:
30499-30510
Publication date:
2014-10-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:8882c189-407c-4e69-8061-82fbd7ff15cf
Source identifiers:
485223
Local pid:
pubs:485223

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