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Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma.

Abstract:

UNLABELLED: The ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein (ASPP) family of proteins regulates apoptosis through interaction with p53 and its family members. This study evaluated the epigenetic regulation of ASPP1 and ASPP2 in hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC) and explores the effects of down-regulation of ASPP1 and ASPP2 on the development of HCC. HCC cell lines and tissues from HCC patients were used to examine...

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Publication status:
Published

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Publisher copy:
10.1002/hep.23247

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Journal:
Hepatology (Baltimore, Md.)
Volume:
51
Issue:
1
Pages:
142-153
Publication date:
2010-01-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:887b16f4-d9ed-4ecd-aa92-309db8bb5b25
Source identifiers:
46216
Local pid:
pubs:46216

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