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Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.

Abstract:

Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2925

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Volume:
46
Issue:
5
Pages:
457-461
Host title:
Nature genetics
Publication date:
2014-05-01
Event location:
United States
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
448019

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