- Abstract:
-
Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that rs20417 may influence prostate cancer risk, using a large case-control study (n(cases)=1608, n(controls)=3058). We found no evidence that rs20417 alters prostate cancer risk (odds ratio (OR(CC and GC ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/pcan.2009.18
-
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- Journal:
- Prostate cancer and prostatic diseases
- Volume:
- 12
- Issue:
- 3
- Pages:
- 296-300
- Publication date:
- 2009
- DOI:
- EISSN:
-
1476-5608
- ISSN:
-
1365-7852
- URN:
-
uuid:887026d3-834d-4bbc-b18b-a5f3f6eaf8f6
- Source identifiers:
-
28178
- Local pid:
- pubs:28178
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.
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