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Journal article

Somatostatin analogues stimulate p27 expression and inhibit the MAP kinase pathway in pituitary tumours.

Abstract:

OBJECTIVES: Somatostatin (SST) analogues play an important role in the medical management of somatotroph pituitary adenomas and new agonists have the potential to be effective in a wider group of pituitary and other tumours. The anti-proliferative effect of SST occurs through multiple mechanisms, one of which is cell-cycle arrest, where p27, a cyclin-dependent kinase inhibitor, is an important regulator. We hypothesised that SST may upregulate p27 protein levels and downregulate the MAP kina...

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Publication status:
Published

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Publisher copy:
10.1530/eje.1.02213

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Journal:
European journal of endocrinology / European Federation of Endocrine Societies
Volume:
155
Issue:
2
Pages:
371-379
Publication date:
2006-08-05
DOI:
EISSN:
1479-683X
ISSN:
0804-4643
URN:
uuid:886faf9e-fadb-4c76-968a-6678a1bfd803
Source identifiers:
138244
Local pid:
pubs:138244

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