Journal article icon

Journal article

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

Abstract:

BRAFV600E mutations occur in 10% of colorectal cancer (CRC) cases, are associated with poor survival and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the biology of poor prognostic BRAFMT CRC. We have used differential gene expression and pathway analyses of untreated stage II and stage III BRAFMT (discovery set: n=31; validation set: n=26) CRC and an siRNA screen to characterize the biology underpinning the BRAFMT subgrou...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1158/1535-7163.mct-17-0603

Authors


More by this author
Role:
Author
ORCID:
0000-0002-7821-2500
Expand authors...
More from this funder
Grant:
C212/A13721 – P.G. Johnston
More from this funder
Grant:
MErCuRIC #602901 (S. Van Schaeybroeck)
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Molecular Cancer Therapeutics Journal website
Volume:
17
Issue:
6
Pages:
1280-1290
Publication date:
2018-02-26
Acceptance date:
2018-02-16
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
Pubs id:
pubs:826969
URN:
uri:886f570f-1d5a-4e2a-8ca5-a4245bf4c541
UUID:
uuid:886f570f-1d5a-4e2a-8ca5-a4245bf4c541
Local pid:
pubs:826969
Language:
English
Keywords:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP