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Journal article

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

Abstract:

Exosomal miRNA transfer is a mechanism for cell-cell communication that is important in the immune response, in the functioning of the nervous system and in cancer. Syncrip/hnRNPQ is a highly conserved RNA-binding protein that mediates the exosomal partition of a set of miRNAs. Here, we report that Syncrip's amino-terminal domain, which was previously thought to mediate protein-protein interactions, is a cryptic, conserved and sequence-specific RNA-binding domain, designated NURR (N-terminal ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-03182-3

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University College London More from this funder
Italian Association for Cancer Research More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
831
Publication date:
2018-02-26
Acceptance date:
2018-01-25
DOI:
ISSN:
2041-1723
Pubs id:
pubs:842734
URN:
uri:8868b05f-8a23-472a-a949-700735295169
UUID:
uuid:8868b05f-8a23-472a-a949-700735295169
Local pid:
pubs:842734
Keywords:

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