- Abstract:
-
Exosomal miRNA transfer is a mechanism for cell-cell communication that is important in the immune response, in the functioning of the nervous system and in cancer. Syncrip/hnRNPQ is a highly conserved RNA-binding protein that mediates the exosomal partition of a set of miRNAs. Here, we report that Syncrip's amino-terminal domain, which was previously thought to mediate protein-protein interactions, is a cryptic, conserved and sequence-specific RNA-binding domain, designated NURR (N-terminal ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 7.1MB)
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- Publisher copy:
- 10.1038/s41467-018-03182-3
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Issue:
- 1
- Pages:
- 831
- Publication date:
- 2018-02-26
- Acceptance date:
- 2018-01-25
- DOI:
- ISSN:
-
2041-1723
- Pubs id:
-
pubs:842734
- URN:
-
uri:8868b05f-8a23-472a-a949-700735295169
- UUID:
-
uuid:8868b05f-8a23-472a-a949-700735295169
- Local pid:
- pubs:842734
- Keywords:
- Copyright holder:
- Castello et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- License:
- CC BY
Journal article
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
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