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Structures of CUG repeats in RNA. Potential implications for human genetic diseases.

Abstract:

Triplet repeats that cause human genetic diseases have been shown to exhibit unusual compact structures in DNA, and in this paper we show that similar structures exist in shorter "normal length" CNG RNA. CUG and control RNAs were made chemically and by in vitro transcription. We find that "normal" short CUG RNAs migrate anomalously fast on non-denaturing gels, compared with control oligos of similar base composition. By contrast, longer tracts approaching clinically relevant lengths appear to...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m202235200

Authors


Pinheiro, P More by this author
Scarlett, G More by this author
Rodger, PM More by this author
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Journal:
The Journal of biological chemistry
Volume:
277
Issue:
38
Pages:
35183-35190
Publication date:
2002-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:8867ae47-2a08-4b28-a0d0-0f3f20b487e8
Source identifiers:
400225
Local pid:
pubs:400225

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