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MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.

Abstract:

Antigen presentation to T cells by MHC molecules is essential for adaptive immune responses. To determine the exact position of a gene affecting expression of MHC molecules, we finely mapped a previously defined rat quantitative trait locus regulating MHC class II on microglia in an advanced intercross line. We identified a small interval including the gene MHC class II transactivator (Mhc2ta) and, using a map over six inbred strains combined with gene sequencing and expression analysis, two ...

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Publication status:
Published

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Publisher copy:
10.1038/ng1544

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Journal:
Nature genetics
Volume:
37
Issue:
5
Pages:
486-494
Publication date:
2005-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:885b5265-0ee6-4d5d-bfa8-9d9d0a488633
Source identifiers:
5629
Local pid:
pubs:5629

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