- Abstract:
-
Antigen presentation to T cells by MHC molecules is essential for adaptive immune responses. To determine the exact position of a gene affecting expression of MHC molecules, we finely mapped a previously defined rat quantitative trait locus regulating MHC class II on microglia in an advanced intercross line. We identified a small interval including the gene MHC class II transactivator (Mhc2ta) and, using a map over six inbred strains combined with gene sequencing and expression analysis, two ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng1544
-
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- Journal:
- Nature genetics
- Volume:
- 37
- Issue:
- 5
- Pages:
- 486-494
- Publication date:
- 2005-05-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:885b5265-0ee6-4d5d-bfa8-9d9d0a488633
- Source identifiers:
-
5629
- Local pid:
- pubs:5629
- Copyright date:
- 2005
Journal article
MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.
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